BioParity.UFO / UAP research

15 papers for “Study limitations”

Results

PaperS7571

Neurological, Cognitive, and Psychological Findings Among Survivors of Ebola Virus Disease From the 1995 Ebola Outbreak in Kikwit, Democratic Republic of Congo: A Cross-sectional Study

J Daniel Kelly, Nicole A Hoff, D’Andre Spencer, Kamy Musene, Matthew S Bramble, David McIlwain, Daniel Okitundu, Travis C Porco, George W Rutherford, M Maria Glymour, Zach Bjornson, Patrick Mukadi, Emile Okitolonda-Wemakoy, Garry P Nolan, Jean Jacques Muyembe-Tamfum, Anne W Rimoin. ebi.ac.uk. August 10, 2018.

A selected 2017 cross-sectional study compared 20 Ebola survivors with 187 contacts from the Kikwit outbreak community. Cognitive and psychological score associations do not establish persistent causal brain injury, clinical diagnoses or 22 years of longitudinal follow-up. Small samples, instrument limitations and inconsistent source values remain explicit. Nolan is a coauthor; no UAP programme is discussed.

Supplied article and supporting text read; original layouts unavailable
PaperS7620

Nanoscopic subcellular imaging enabled by ion beam tomography

Ahmet F Coskun, Guojun Han, Shambavi Ganesh, Shih-Yu Chen, Xavier Rovira Clavé, Stefan Harmsen, Sizun Jiang, Christian M Schürch, Yunhao Bai, Chuck Hitzman, Garry P Nolan. ebi.ac.uk. February 4, 2021.

The authors demonstrate destructive ion-beam imaging and computational reconstruction in fixed cells and selected tissue. Calibration resolution, localization precision and theoretical capability remain distinct. Nested depth slices and reconstruction-derived ground truth limit independence. The method is a research demonstration, with no clinical efficacy or UAP finding established.

Complete supplied main, mathematics and figures; supplements unreceived
PaperS7617

ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs

Ivan T. Lee et al.. ebi.ac.uk. October 28, 2020.

The authors localize ACE2 staining to respiratory cilia and compare receptor expression across medication groups. Small subgroups, treatment indication, age imbalance and retrospective confounding qualify the comparisons. Negative or nonsignificant results do not establish equivalence, infection protection or clinical benefit. The study reports localization and expression rather than a treatment trial.

Complete supplied main, figures and two supplements; peer review unreviewed
PaperS7624

Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front

Christian M Schürch, Salil S Bhate, Graham L Barlow, Darci J Phillips, Luca Noti, Inti Zlobec, Pauline Chu, Sarah Black, Janos Demeter, David R McIlwain, Shigemi Kinoshita, Nikolay Samusik, Yury Goltsev, Garry P Nolan. ebi.ac.uk. September 3, 2020.

The authors analyze spatial immune patterns in selected colorectal-cancer tissue. Thirty-five patients supply140 dependent tissue cores; repeated cells, regions and holdouts do not create new cohorts. Survival findings and correlation-based “communication” are exploratory. A linked correction adds Shigemi Kinoshita to the author list. No clinical efficacy or UAP finding is established.

Complete supplied main, figures and correction; bounded supplementary review
PaperS7610

Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity

Lu Cui, Shih-Yu Chen, Tristan Lerbs, Jin-Wook Lee, Pablo Domizi, Sydney Gordon, Yong-hun Kim, Garry Nolan, Paola Betancur, Gerlinde Wernig. ebi.ac.uk. June 3, 2020.

The authors report JUN-associated changes in lung fibroblasts and test mechanisms and interventions in engineered cultures and mouse models. Eleven end-stage cases and three cancer-resection controls define the human comparison. Preclinical findings, sampling biases and explicit toxicity cautions prevent claims of proven treatment benefit or safety in patients.

Complete supplied main text; bounded supplemental visuals
PaperS7603

Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line

Yapeng Su, Melissa E Ko, Hanjun Cheng, Ronghui Zhu, Min Xue, Jessica Wang, Jihoon W Lee, Luke Frankiw, Alexander Xu, Stephanie Wong, Lidia Robert, Kaitlyn Takata, Dan Yuan, Yue Lu, Sui Huang, Antoni Ribas, Raphael Levine, Garry P Nolan, Wei Wei, Sylvia K Plevritis, Guideng Li, David Baltimore, James R Heath. ebi.ac.uk. May 11, 2020.

The authors infer different routes to early drug tolerance within one cultured melanoma cell line and test selected drug combinations. The inferred barrier was not measured. Negative inhibitor assays, dependence among cell snapshots and possible normal-tissue toxicity qualify the results; clinical efficacy was not established.

Complete supplied main text; partial supplemental visuals
PaperS7608

Ultra-high throughput single-cell analysis of proteins and RNAs by split-pool synthesis

Maeve O’Huallachain, Felice-Alessio Bava, Mary Shen, Carolina Dallett, Sri Paladugu, Nikolay Samusik, Simon Yu, Razika Hussein, Grantland R. Hillman, Samuel Higgins, Melanie Lou, Angelica Trejo, Laura Qin, Yu Chuan Tai, Shigemi M. Kinoshita, Astraea Jager, Deval Lashkari, Yury Goltsev, Sedide Ozturk, Garry P. Nolan. ebi.ac.uk. May 7, 2020.

The authors demonstrate split-pool barcoding for protein and targeted RNA measurements in cell lines, human blood-cell material and mouse cells. Large theoretical barcode capacity is distinct from measured event recovery. Uneven RNA detection, cell losses, exclusions, doublets and source discrepancies limit interpretation; no clinical or UAP validation follows.

Complete supplied main and correction text; partial supplemental visuals
PaperS7613

Cellular Signaling Analysis shows antiviral, ribavirin-mediated ribosomal signaling modulation

Xianting Ding, Peter O Krutzik, Amir Ali Ghaffari, Yixiu Zhaozhi, Daniel Miranda Jr, Genhong Cheng, Chih-Ming Ho, Garry P Nolan, David Jesse Sanchez. ebi.ac.uk. September 9, 2019.

The authors connect antiviral treatment, infection and ribosomal signaling in selected cell assays and a short mouse model. Timing, inadequate low-dose response, broad effects at higher doses, declining viability and delayed animal results qualify the mechanism. These findings do not demonstrate treatment benefit or safety in people.

Complete supplied main and meaningful images; raw study unreviewed
PaperS7599

Complex Mammalian-like Hematopoietic System Found in a Colonial Chordate

Benyamin Rosental, Mark Kowarsky, Jun Seita, Daniel M. Corey, Katherine J. Ishizuka, Karla J. Palmeri, Shih-Yu Chen, Rahul Sinha, Jennifer Okamoto, Gary Mantalas, Lucia Manni, Tal Raveh, D. Nathaniel Clarke, Jonathan M. Tsai, Aaron M. Newman, Norma F. Neff, Garry P. Nolan, Stephen R. Quake, Irving L. Weissman, Ayelet Voskoboynik. ebi.ac.uk. December 5, 2018.

The authors report candidate blood-forming and immune-cell populations in a colonial tunicate, using expression comparisons, transplantation and functional assays. Mammalian similarities remain qualified by missing lymphoid signatures, cross-reactivity, autofluorescence and incomplete stem-cell benchmarks.

Complete supplied manuscript and tables; apparatus missing
PaperS7614

Deep Profiling of Mouse Splenic Architecture with CODEX Multiplexed Imaging

Yury Goltsev, Nikolay Samusik, Julia Kennedy-Darling, Salil Bhate, Matthew Hale, Gustavo Vazquez, Sarah Black, Garry P. Nolan. ebi.ac.uk. August 9, 2018.

CODEX imaging maps cells and neighborhoods in nine mouse spleens. Most changing contacts track cell abundance rather than stronger inferred interactions. Neighborhood associations leave causal direction open. Image classification used test-set patches for tuning, and reported precision is not clinical accuracy. Financial interests and processing limits are retained.

Complete supplied main, figures, S1/S2 cells and S4 PDF
PaperS7524

Single-cell spatial pharmacobiology identifies conserved stromal barriers to therapeutic antibody delivery in human solid tumors

Guolan Lu, John W Hickey, Maximilian Haist, Xulei Qin, Emily Zhao, Abdullah Naveed, Erna Forgo, Marc-A Baertsch, Lucas Mani, Xavier Rovira-Clavé, Andrey Finegersh, Yury Goltsev, Chiara Caraccio, Nynke S van den Berg, Marisa Hom, Deana R Colburg, Brock A Martin, Christina S Kong, Natalie S Lui, George A Fisher, A Dimitrios Colevas, Robert B West, Greg M Thurber, George A Poultsides, Garry P Nolan, Eben L Rosenthal. ebi.ac.uk. June 3, 2026.

An exploratory oncology study examines antibody distribution and tissue organization in small, nested patient cohorts. Several nominal associations weaken after statistical correction or patient sensitivity checks. Alternate measurement on the same tissues adds a different method, without independent patient replication or proven clinical benefit.

Supplied manuscript, figures and supplement read
PaperS7598

TRAIL-induced variation of cell signaling states provides nonheritable resistance to apoptosis

Reema Baskar, Harris G Fienberg, Zumana Khair, Patricia Favaro, Sam Kimmey, Douglas R Green, Garry P Nolan, Sylvia Plevritis, Sean C Bendall. ebi.ac.uk. November 8, 2019.

This cultured-cell study examines variation in resistance to TRAIL-induced apoptosis. Responses differ across cell lines, and no universal resistant signaling state emerged. Reviewers questioned replication, causality and selected-marker diversity; the revised paper and small surviving fractions retain those limits.

Complete supplied main text and qualified apparatus reviewed

A curated public selection. Source review describes what was read; it does not establish that a claim is true. Our research approach