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Paper · S7524

Single-cell spatial pharmacobiology identifies conserved stromal barriers to therapeutic antibody delivery in human solid tumors

Guolan Lu, John W Hickey, Maximilian Haist, Xulei Qin, Emily Zhao, Abdullah Naveed, Erna Forgo, Marc-A Baertsch, Lucas Mani, Xavier Rovira-Clavé, Andrey Finegersh, Yury Goltsev, Chiara Caraccio, Nynke S van den Berg, Marisa Hom, Deana R Colburg, Brock A Martin, Christina S Kong, Natalie S Lui, George A Fisher, A Dimitrios Colevas, Robert B West, Greg M Thurber, George A Poultsides, Garry P Nolan, Eben L Rosenthal. ebi.ac.uk. June 3, 2026.

An exploratory oncology study examines antibody distribution and tissue organization in small, nested patient cohorts. Several nominal associations weaken after statistical correction or patient sensitivity checks. Alternate measurement on the same tissues adds a different method, without independent patient replication or proven clinical benefit.

Read the paper at ebi.ac.uk

What we checked

All 206 supplied author-manuscript XML units, 71 reference entries, 12 main/extended figures, and all 31 received supplement pages with 16 figures and Tables 1, 4 and 5 were reviewed. Publication June 3, 2026 and repository July 23 are distinct.

Supplied manuscript, figures and supplement read


How we check sources

Not checked yet

  • Referenced supplementary Tables 2 and 3, publisher-layout PDF, separate source data, reporting summary, raw datasets, cited study bodies and linked code were not reviewed.

Source limitations

  • Small cohorts and multiple regions per person limit generalization. Correlation lacks direct causal testing; imaging exposure and target-engagement proxies do not establish clinical response. Disclosures and qualified statistical findings remain explicit. This supplies scholarly background, without a UAP-exposed cohort or programme account.

Cite this record

Guolan Lu, John W Hickey, Maximilian Haist, Xulei Qin, Emily Zhao, Abdullah Naveed, Erna Forgo, Marc-A Baertsch, Lucas Mani, Xavier Rovira-Clavé, Andrey Finegersh, Yury Goltsev, Chiara Caraccio, Nynke S van den Berg, Marisa Hom, Deana R Colburg, Brock A Martin, Christina S Kong, Natalie S Lui, George A Fisher, A Dimitrios Colevas, Robert B West, Greg M Thurber, George A Poultsides, Garry P Nolan, Eben L Rosenthal. Single-cell spatial pharmacobiology identifies conserved stromal barriers to therapeutic antibody delivery in human solid tumors. June 3, 2026. BioParity S7524. https://bioparity.io/sources/S7524
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