Paper · S7613
Cellular Signaling Analysis shows antiviral, ribavirin-mediated ribosomal signaling modulation
The authors connect antiviral treatment, infection and ribosomal signaling in selected cell assays and a short mouse model. Timing, inadequate low-dose response, broad effects at higher doses, declining viability and delayed animal results qualify the mechanism. These findings do not demonstrate treatment benefit or safety in people.
Read the paper at ebi.ac.ukWhat we checked
Read54,324 XML characters in seven complete returns,37 references,48 physical table cells with nine blank cells, and14 meaningful image objects: graphical abstract, seven main and six supplemental figures. Read the data-on-request record. Nolan’s supplied role is manuscript writing and experimental design. September9 publication is distinct from separately verified November2019 issue metadata.
Complete supplied main and meaningful images; raw study unreviewed
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- Original main PDF, every fine image label, raw data and code remain unreviewed. The native XML supplies no PMCID version or competing-interests statement; absence does not mean no conflicts. Raw data were neither received nor requested.
- SL0101 has a higher printed infection titer on day2 and lower on day3. A seventy-fold/day3 prose claim conflicts with printed values. Caption units, treatment labels, mean/median fluorescence, SD/SEM, mouse-strain wording and replication levels remain unresolved.
- Cell preparations, images, experiments and mice are distinct units. Prior combination work is dependent. Higher-dose effects involve multiple signaling pathways and reduced viability; historical treatment assertions are not current clinical guidance or UAP evidence.
Cite this record
Xianting Ding, Peter O Krutzik, Amir Ali Ghaffari, Yixiu Zhaozhi, Daniel Miranda Jr, Genhong Cheng, Chih-Ming Ho, Garry P Nolan, David Jesse Sanchez. Cellular Signaling Analysis shows antiviral, ribavirin-mediated ribosomal signaling modulation. September 9, 2019. BioParity S7613. https://bioparity.io/sources/S7613Record data (JSON)