{"apiVersion":"1","version":"sha256:faade27e0b75b2aca6311142ff65347b4dacc153e8d28cbdf0e8a237319331f9","data":{"id":"S7613","title":"Cellular Signaling Analysis shows antiviral, ribavirin-mediated ribosomal signaling modulation","authors":["Xianting Ding","Peter O Krutzik","Amir Ali Ghaffari","Yixiu Zhaozhi","Daniel Miranda Jr","Genhong Cheng","Chih-Ming Ho","Garry P Nolan","David Jesse Sanchez"],"publishedDate":"2019-09-09","format":"Paper","url":"https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7114107/fullTextXML","summary":"The authors connect antiviral treatment, infection and ribosomal signaling in selected cell assays and a short mouse model. Timing, inadequate low-dose response, broad effects at higher doses, declining viability and delayed animal results qualify the mechanism. These findings do not demonstrate treatment benefit or safety in people.","subjects":["Garry Nolan research","Antiviral signaling","Study limitations"],"people":["Garry Nolan"],"review":{"label":"Complete supplied main and meaningful images; raw study unreviewed","scope":"Read54,324 XML characters in seven complete returns,37 references,48 physical table cells with nine blank cells, and14 meaningful image objects: graphical abstract, seven main and six supplemental figures. Read the data-on-request record. Nolan’s supplied role is manuscript writing and experimental design. September9 publication is distinct from separately verified November2019 issue metadata.","gaps":["Original main PDF, every fine image label, raw data and code remain unreviewed. The native XML supplies no PMCID version or competing-interests statement; absence does not mean no conflicts. Raw data were neither received nor requested.","SL0101 has a higher printed infection titer on day2 and lower on day3. A seventy-fold/day3 prose claim conflicts with printed values. Caption units, treatment labels, mean/median fluorescence, SD/SEM, mouse-strain wording and replication levels remain unresolved.","Cell preparations, images, experiments and mice are distinct units. Prior combination work is dependent. Higher-dose effects involve multiple signaling pathways and reduced viability; historical treatment assertions are not current clinical guidance or UAP evidence."]},"familyId":"DOI-10.1016-J.ANTIVIRAL.2019.104598","citationUrl":"https://bioparity.io/sources/S7613","citation":"Xianting Ding, Peter O Krutzik, Amir Ali Ghaffari, Yixiu Zhaozhi, Daniel Miranda Jr, Genhong Cheng, Chih-Ming Ho, Garry P Nolan, David Jesse Sanchez. Cellular Signaling Analysis shows antiviral, ribavirin-mediated ribosomal signaling modulation. September 9, 2019. BioParity S7613. https://bioparity.io/sources/S7613"}}