BioParity.UFO / UAP research

63 sources for “Research methods”

Results

PaperS7688

Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma

Darci Phillips, Magdalena Matusiak, Belén Rivero Gutierrez, Salil S Bhate, Graham L Barlow, Sizun Jiang, Janos Demeter, Kimberly S Smythe, Robert H Pierce, Steven P Fling, Nirasha Ramchurren, Martin A Cheever, Yury Goltsev, Robert B West, Michael S Khodadoust, Youn H Kim, Christian M Schürch, Garry P Nolan. ebi.ac.uk. November 18, 2021.

This observational tissue analysis links immune-cell topography to pembrolizumab response in14selected lymphoma patients from an earlier24-patient trial. Seventy regions and large cell counts remain nested within those patients. Assay validation and resampling reuse the same cohort, without an independent clinical test. Several abundance and signature measures were null; the proposed chemokine mechanism is not causally demonstrated. Nolan is a corresponding coauthor/joint supervisor. Published government grants and commercial/patent disclosures remain attributed, without establishing a classified approach or UAP programme.

Complete specialist supplied XML text; native graphics unreviewed
PaperS7747

Erosion of Icy Interstellar Objects by Cosmic Rays and Implications for ‘Oumuamua

Vo Hong Minh Phan, Thiem Hoang, Abraham Loeb. arxiv.org. October 28, 2021.

Phan, Hoang and Loeb model erosion and modification of icy interstellar objects under assumed cosmic-ray, material and travel conditions. Prior observations and fits support theoretical predictions rather than new detections or demonstrated composition.

Complete supplied seven-page manuscript; conditional erosion model
PaperS7745

The Mass Budget Necessary to Explain ‘Oumuamua as a Nitrogen Iceberg

Amir Siraj, Abraham Loeb. arxiv.org. October 15, 2021.

Siraj and Loeb assess whether nitrogen-ice fragments could account for the earlier Oumuamua detection. Their conclusion depends on population and mass-budget assumptions; no new data are generated or analyzed.

Complete supplied three-page manuscript; conditional mass-budget model
PaperS7685

Subcellular localization of biomolecules and drug distribution by high-definition ion beam imaging

Xavier Rovira-Clavé, Sizun Jiang, Yunhao Bai, Bokai Zhu, Graham Barlow, Salil Bhate, Ahmet F Coskun, Guojun Han, Chin-Min Kimmy Ho, Chuck Hitzman, Shih-Yu Chen, Felice-Alessio Bava, Garry P Nolan. ebi.ac.uk. July 30, 2021.

This cultured-cell imaging study maps biomolecules and drug distribution at fine spatial scales, with limited skin-tissue validation. Small cell samples and nested voxels limit generalization; 33 fields/cells across treatment groups came from one experiment. The proposed nuclear-pore pumping mechanism is an interpretation, without a demonstrated causal intervention or clinical outcome. Acknowledged NIH, Army and foundation support does not establish a secret approach or UAP programme. Nolan is a corresponding author and joint supervisor. The paper declares no competing interests; native graphics, supplements and underlying data remain unreviewed.

Complete specialist supplied XML text; native graphics unreviewed
PaperS7744

Interstellar Objects Outnumber Solar System Objects in the Oort Cloud

Amir Siraj, Abraham Loeb. arxiv.org. July 22, 2021.

Siraj and Loeb infer a potentially large interstellar population from prior observations and population assumptions. The paper introduces no new data; selection, size distributions and model sensitivity limit its abundance estimates.

Complete supplied four-page manuscript; conditional abundance model
PaperS7620

Nanoscopic subcellular imaging enabled by ion beam tomography

Ahmet F Coskun, Guojun Han, Shambavi Ganesh, Shih-Yu Chen, Xavier Rovira Clavé, Stefan Harmsen, Sizun Jiang, Christian M Schürch, Yunhao Bai, Chuck Hitzman, Garry P Nolan. ebi.ac.uk. February 4, 2021.

The authors demonstrate destructive ion-beam imaging and computational reconstruction in fixed cells and selected tissue. Calibration resolution, localization precision and theoretical capability remain distinct. Nested depth slices and reconstruction-derived ground truth limit independence. The method is a research demonstration, with no clinical efficacy or UAP finding established.

Complete supplied main, mathematics and figures; supplements unreceived
PaperS7750

Destruction of molecular hydrogen ice and Implications for 1I/2017 U1 (`Oumuamua)

Thiem Hoang, Abraham Loeb. arxiv.org. August 12, 2020.

Hoang and Loeb model destruction and formation of pure hydrogen ice under assumed radiation, material and cloud conditions. They challenge one proposed explanation of Oumuamua while retaining environmental exceptions; no hydrogen object is observed and no artificial origin is established.

Complete supplied eight-page manuscript; conditional hydrogen-ice model
PaperS7608

Ultra-high throughput single-cell analysis of proteins and RNAs by split-pool synthesis

Maeve O’Huallachain, Felice-Alessio Bava, Mary Shen, Carolina Dallett, Sri Paladugu, Nikolay Samusik, Simon Yu, Razika Hussein, Grantland R. Hillman, Samuel Higgins, Melanie Lou, Angelica Trejo, Laura Qin, Yu Chuan Tai, Shigemi M. Kinoshita, Astraea Jager, Deval Lashkari, Yury Goltsev, Sedide Ozturk, Garry P. Nolan. ebi.ac.uk. May 7, 2020.

The authors demonstrate split-pool barcoding for protein and targeted RNA measurements in cell lines, human blood-cell material and mouse cells. Large theoretical barcode capacity is distinct from measured event recovery. Uneven RNA detection, cell losses, exclusions, doublets and source discrepancies limit interpretation; no clinical or UAP validation follows.

Complete supplied main and correction text; partial supplemental visuals
PaperS7500

Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models

Bahareh Ajami, Nikolay Samusik, Peter Wieghofer, Peggy P. Ho, Andrea Crotti, Zach Bjornson, Marco Prinz, Wendy J. Fantl, Garry P. Nolan, Lawrence Steinman. med.stanford.edu. March 5, 2018.

Ajami, Nolan and colleagues analyse brain myeloid populations in mouse disease models. Mouse treatment findings do not establish human therapy or UAP-related illness. Pooling, statistical assumptions and inconsistencies constrain interpretation.

Paper, methods, figures and checklist read
PaperS7742

Fast radio bursts: the observational case for a Galactic origin

Dan Maoz, Abraham Loeb, Yossi Shvartzvald, Monika Sitek, Michael Engel, Flavien Kiefer, Marcin Kiraga, Amir Levi, Tsevi Mazeh, Michał Pawlak, R. Michael Rich, Lev Tal-Or, Lukasz Wyrzykowski. arxiv.org. September 8, 2015.

Maoz, Loeb and colleagues compare optical variability with historical radio-burst fields and propose stellar counterparts. Their association calculations depend on selection and assumptions; simultaneous counterpart evidence and raw-data replication are missing.

Complete supplied nine-page manuscript; counterpart and version gaps
PaperS7739

SETI via Leakage from Light Sails in Exoplanetary Systems

James Guillochon, Abraham Loeb. arxiv.org. September 3, 2015.

Guillochon and Loeb model possible leakage from hypothetical light-sail propulsion systems. Simulated observing windows depend on assumed inhabited systems and operating choices; the paper supplies no detection or deployed apparatus.

Complete supplied v2 text and native layouts; conditional model

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