Paper · S7500
Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models
Ajami, Nolan and colleagues analyse brain myeloid populations in mouse disease models. Mouse treatment findings do not establish human therapy or UAP-related illness. Pooling, statistical assumptions and inconsistencies constrain interpretation.
Read the paper at med.stanford.eduWhat we checked
All 16 supplied pages were read and visually inspected: printed pages 541–551, methods, reporting summary, six main figures and 62 references. Online publication is March 5, 2018; issue date is April.
Paper, methods, figures and checklist read
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- Separate supplementary figures 1–13, tables 1–2, underlying FCS/raw data, code execution and independent replication were not reviewed.
Source limitations
- Cell counts are not independent animal counts. Prophylaxis day 0/day 1 and supplementary panel mappings disagree. Nolan advised design, analysis and interpretation; grant acknowledgments do not establish a secret programme.
Cite this record
Bahareh Ajami, Nikolay Samusik, Peter Wieghofer, Peggy P. Ho, Andrea Crotti, Zach Bjornson, Marco Prinz, Wendy J. Fantl, Garry P. Nolan, Lawrence Steinman. Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models. March 5, 2018. BioParity S7500. https://bioparity.io/sources/S7500Record data (JSON)