Results

PaperS7759

An Exomoon Survey of 70 Cool Giant Exoplanets and the New Candidate Kepler-1708 b-i

David Kipping, Steve Bryson, Chris Burke, Jessie Christiansen, Kevin Hardegree-Ullman, Billy Quarles, Brad Hansen, Judit Szulágyi, Alex Teachey. arxiv.org. January 12, 2022.

A survey of70 cool giant planets reports a tentative exomoon candidate. Two transits and dependent treatments of Kepler data leave ordinary noise, blend and other-planet alternatives. Statistical planet validation and moon tests are separate; this is astronomy background, with no life or UAP detection.

Full supplied v1 manuscript; original and model checks remain open
PaperS7688

Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma

Darci Phillips, Magdalena Matusiak, Belén Rivero Gutierrez, Salil S Bhate, Graham L Barlow, Sizun Jiang, Janos Demeter, Kimberly S Smythe, Robert H Pierce, Steven P Fling, Nirasha Ramchurren, Martin A Cheever, Yury Goltsev, Robert B West, Michael S Khodadoust, Youn H Kim, Christian M Schürch, Garry P Nolan. ebi.ac.uk. November 18, 2021.

This observational tissue analysis links immune-cell topography to pembrolizumab response in14selected lymphoma patients from an earlier24-patient trial. Seventy regions and large cell counts remain nested within those patients. Assay validation and resampling reuse the same cohort, without an independent clinical test. Several abundance and signature measures were null; the proposed chemokine mechanism is not causally demonstrated. Nolan is a corresponding coauthor/joint supervisor. Published government grants and commercial/patent disclosures remain attributed, without establishing a classified approach or UAP programme.

Complete specialist supplied XML text; native graphics unreviewed
PaperS7747

Erosion of Icy Interstellar Objects by Cosmic Rays and Implications for ‘Oumuamua

Vo Hong Minh Phan, Thiem Hoang, Abraham Loeb. arxiv.org. October 28, 2021.

Phan, Hoang and Loeb model erosion and modification of icy interstellar objects under assumed cosmic-ray, material and travel conditions. Prior observations and fits support theoretical predictions rather than new detections or demonstrated composition.

Complete supplied seven-page manuscript; conditional erosion model
PaperS7745

The Mass Budget Necessary to Explain ‘Oumuamua as a Nitrogen Iceberg

Amir Siraj, Abraham Loeb. arxiv.org. October 15, 2021.

Siraj and Loeb assess whether nitrogen-ice fragments could account for the earlier Oumuamua detection. Their conclusion depends on population and mass-budget assumptions; no new data are generated or analyzed.

Complete supplied three-page manuscript; conditional mass-budget model
PaperS7553

Strategies for Accurate Cell Type Identification in CODEX Multiplexed Imaging Data

John W. Hickey, Yuqi Tan, Garry P. Nolan, Yury Goltsev. ebi.ac.uk. August 13, 2021.

The study compares 20 cell-annotation pipelines using four healthy-colon tissue blocks from one donor. Agreement improves with broader labels, but both reference sets use the same images and one explicitly favors a pipeline being evaluated. The authors recommend checking expression patterns and image locations when assigning cell types. Marker counts, a worked F-score example and several caption or settings inconsistencies remain documented. These results do not establish universal clinical accuracy or a UAP connection.

Supplied text and scoped apparatus read
PaperS7685

Subcellular localization of biomolecules and drug distribution by high-definition ion beam imaging

Xavier Rovira-Clavé, Sizun Jiang, Yunhao Bai, Bokai Zhu, Graham Barlow, Salil Bhate, Ahmet F Coskun, Guojun Han, Chin-Min Kimmy Ho, Chuck Hitzman, Shih-Yu Chen, Felice-Alessio Bava, Garry P Nolan. ebi.ac.uk. July 30, 2021.

This cultured-cell imaging study maps biomolecules and drug distribution at fine spatial scales, with limited skin-tissue validation. Small cell samples and nested voxels limit generalization; 33 fields/cells across treatment groups came from one experiment. The proposed nuclear-pore pumping mechanism is an interpretation, without a demonstrated causal intervention or clinical outcome. Acknowledged NIH, Army and foundation support does not establish a secret approach or UAP programme. Nolan is a corresponding author and joint supervisor. The paper declares no competing interests; native graphics, supplements and underlying data remain unreviewed.

Complete specialist supplied XML text; native graphics unreviewed
PaperS7744

Interstellar Objects Outnumber Solar System Objects in the Oort Cloud

Amir Siraj, Abraham Loeb. arxiv.org. July 22, 2021.

Siraj and Loeb infer a potentially large interstellar population from prior observations and population assumptions. The paper introduces no new data; selection, size distributions and model sensitivity limit its abundance estimates.

Complete supplied four-page manuscript; conditional abundance model
PaperS7550

Adjacent Cell Marker Lateral Spillover Compensation and Reinforcement for Multiplexed Images

Yunhao Bai, Bokai Zhu, Xavier Rovira-Clave, Han Chen, Maxim Markovic, Chi Ngai Chan, Tung-Hung Su, David R. McIlwain, Jacob D. Estes, Leeat Keren, Garry P. Nolan, Sizun Jiang. ebi.ac.uk. July 5, 2021.

REDSEA compensates signal leakage between adjacent segmented cells. Published tests compare correction choices against a fallible manual reference and reused imaging data. Retaining signal and removing ambiguous classifications involve tradeoffs; poor segmentation and several other contamination mechanisms remain unresolved. Source counts, caption panels, equation notation and channel lists conflict. Nolan’s declared instrument-company financial interest and funding disclaimer remain part of the evidence.

Supplied article and published supplements read
PaperS7677

Virtual and augmented reality for biomedical applications

Mythreye Venkatesan, Harini Mohan, Justin R Ryan, Christian M Schürch, Garry P Nolan, David H Frakes, Ahmet F Coskun. ebi.ac.uk. July 2021.

This Nolan-coauthored review surveys biomedical virtual and augmented reality and presents illustrative case studies. It retains practical limitations: some training performs worse than hands-on instruction, a surgical comparison found no significant improvement in several broader outcomes, and image quality, tracking, cost, privacy and discomfort constrain use. Demonstrations and reported funding are distinct from proven clinical benefit or classified UAP access.

Complete supplied XML text; original figures and supplements unreviewed
PaperS7561

Highly Multiplexed Phenotyping of Immunoregulatory Proteins in the Tumor Microenvironment by CODEX Tissue Imaging

Darci Phillips, Christian M Schürch, Michael S Khodadoust, Youn H Kim, Garry P Nolan, Sizun Jiang. ebi.ac.uk. May 19, 2021.

The authors develop a multiplexed imaging panel using eight previously treated tumor specimens. The 25,456 analyzed cells are nested within eight sampled cores, rather than independent patients. Cell types combine clustering with manual refinement; spatial marker patterns do not establish functional causation or clinical treatment prediction. Nolan supervised and revised the study, while Jiang is corresponding author. Channel labels, figure pointers and plotted units remain inconsistent in the supplied source.

Complete supplied text and received apparatus read
PaperS7733

Detectability of Artificial Lights from Proxima b

Elisa Tabor, Abraham Loeb. arxiv.org. May 17, 2021.

Tabor and Loeb forecast detectability of hypothetical artificial illumination on Proxima b. This is not a detection. The paper acknowledges an estimated instrument noise floor ten times its predicted signal.

Supplied preprint text and native layouts; conditional model
PaperS7560

Highly multiplexed tissue imaging using repeated oligonucleotide exchange reaction

Julia Kennedy‐Darling, Salil S Bhate, John W Hickey, Sarah Black, Graham L Barlow, Gustavo Vazquez, Vishal G Venkataraaman, Nikolay Samusik, Yury Goltsev, Christian M Schürch, Garry P Nolan. ebi.ac.uk. March 10, 2021.

The authors demonstrate repeated three-color imaging of DNA-tagged antibodies on five human tissue sections from five donors. Millions of segmented cells do not become independent human subjects. Barcode and repeated-cycle validation experiments each have one experimental replicate. Cell-type assignment and spatial associations depend on segmentation, markers and manual annotation. Barcode counts, omitted sequences, reagent labels, geometry and timing remain inconsistent in the supplied material. Nolan is a cosenior and corresponding coauthor.

Complete supplied text and received apparatus read

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