BioParity.UFO / UAP research

140 papers

Results

PaperS7718

Turning up the heat on `Oumuamua

John C. Forbes, Abraham Loeb. arxiv.org. January 2, 2019.

Forbes and Loeb forecast near-Sun interstellar-body encounters and propose spectroscopy. Encounter rates and candidate probabilities depend on uncertain density, orientation, population and detection assumptions. Listed probabilities do not confirm individual origins. Ordinary cometary explanations, bound-orbit caveats and an ISON non-detection remain explicit. Parameter and catalogue-filter discrepancies are unresolved. Forbes’s fellowship is distinct from work-level grant support; neither establishes government access.

Received written text and native layouts; original-record and interpretation gaps
PaperS7599

Complex Mammalian-like Hematopoietic System Found in a Colonial Chordate

Benyamin Rosental, Mark Kowarsky, Jun Seita, Daniel M. Corey, Katherine J. Ishizuka, Karla J. Palmeri, Shih-Yu Chen, Rahul Sinha, Jennifer Okamoto, Gary Mantalas, Lucia Manni, Tal Raveh, D. Nathaniel Clarke, Jonathan M. Tsai, Aaron M. Newman, Norma F. Neff, Garry P. Nolan, Stephen R. Quake, Irving L. Weissman, Ayelet Voskoboynik. ebi.ac.uk. December 5, 2018.

The authors report candidate blood-forming and immune-cell populations in a colonial tunicate, using expression comparisons, transplantation and functional assays. Mammalian similarities remain qualified by missing lymphoid signatures, cross-reactivity, autofluorescence and incomplete stem-cell benchmarks.

Complete supplied manuscript and tables; apparatus missing
PaperS7589

Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis

Jared M. Churko, Priyanka Garg, Barbara Treutlein, Meenakshi Venkatasubramanian, Haodi Wu, Jaecheol Lee, Quinton N. Wessells, Shih-Yu Chen, Wen-Yi Chen, Kashish Chetal, Gary Mantalas, Norma Neff, Eric Jabart, Arun Sharma, Garry P. Nolan, Nathan Salomonis, Joseph C. Wu. ebi.ac.uk. November 21, 2018.

The study analyzes heterogeneity in cultured cardiac differentiation and tests selected regulators. Selected cells and related perturbations provide conditional support, rather than independent donor or clinical replication. A reporting-summary conflict and several negative results remain unresolved.

Supplied main text read; large workbooks partial
PaperS7477

Could Solar Radiation Pressure Explain 'Oumuamua's Peculiar Acceleration?

Shmuel Bialy, Abraham Loeb. arxiv.org. October 26, 2018.

Bialy and Loeb develop a conditional radiation-pressure explanation for ’Oumuamua’s acceleration. Thin natural material and an artificial sail are discussed as possibilities; the calculations do not identify a spacecraft.

Preprint text and figures read
PaperS7571

Neurological, Cognitive, and Psychological Findings Among Survivors of Ebola Virus Disease From the 1995 Ebola Outbreak in Kikwit, Democratic Republic of Congo: A Cross-sectional Study

J Daniel Kelly, Nicole A Hoff, D’Andre Spencer, Kamy Musene, Matthew S Bramble, David McIlwain, Daniel Okitundu, Travis C Porco, George W Rutherford, M Maria Glymour, Zach Bjornson, Patrick Mukadi, Emile Okitolonda-Wemakoy, Garry P Nolan, Jean Jacques Muyembe-Tamfum, Anne W Rimoin. ebi.ac.uk. August 10, 2018.

A selected 2017 cross-sectional study compared 20 Ebola survivors with 187 contacts from the Kikwit outbreak community. Cognitive and psychological score associations do not establish persistent causal brain injury, clinical diagnoses or 22 years of longitudinal follow-up. Small samples, instrument limitations and inconsistent source values remain explicit. Nolan is a coauthor; no UAP programme is discussed.

Supplied article and supporting text read; original layouts unavailable
PaperS7614

Deep Profiling of Mouse Splenic Architecture with CODEX Multiplexed Imaging

Yury Goltsev, Nikolay Samusik, Julia Kennedy-Darling, Salil Bhate, Matthew Hale, Gustavo Vazquez, Sarah Black, Garry P. Nolan. ebi.ac.uk. August 9, 2018.

CODEX imaging maps cells and neighborhoods in nine mouse spleens. Most changing contacts track cell abundance rather than stronger inferred interactions. Neighborhood associations leave causal direction open. Image classification used test-set patches for tuning, and reported precision is not clinical accuracy. Financial interests and processing limits are retained.

Complete supplied main, figures, S1/S2 cells and S4 PDF
PaperS7639

An Introduction to Influence Theory: Kinematics and Dynamics

Kevin H. Knuth, James L. Walsh. arxiv.org. July 20, 2018.

Knuth and Walsh develop a model of directed influence with coordinated observers, recovering relativistic kinematics and event-count action in1+1 dimensions. Their treatment of force and time dilation has weak-influence and other approximation limits. The higher-dimensional extension remains unfinished; this is theoretical work rather than empirical UFO evidence.

Complete supplied version2 text; qualified figures
PaperS7641

Lattices and Their Consistent Quantification

Kevin H. Knuth. arxiv.org. July 20, 2018.

Knuth derives additive, product and contextual chain rules under specified lattice, continuity, identity/inverse, compatibility and distributivity assumptions. Signed and non-partition relevance can be negative. Mathematical examples and prospective applications supply no new UAP observations. Native entropy-label and version-date conflicts remain unresolved.

Complete supplied paper text; qualified native figures and tables
PaperS7583

SRC/ABL inhibition disrupts CRLF2-driven signaling to induce cell death in B-cell acute lymphoblastic leukemia

Jolanda Sarno, Angela M Savino, Chiara Buracchi, Chiara Palmi, Stefania Pinto, Cristina Bugarin, Astraea Jager, Silvia Bresolin, Ruth C Barber, Daniela Silvestri, Shai Israeli, Martin JS Dyer, Giovanni Cazzaniga, Garry P Nolan, Andrea Biondi, Kara L Davis, Giuseppe Gaipa. ebi.ac.uk. May 1, 2018.

A preclinical leukemia study reports signaling and cell-viability responses to SRC/ABL inhibition. Results vary across selected samples, cell models and treatment conditions. Negative findings, limited sample availability and statistical inconsistencies qualify the claims. The supplied main text and supplement are read; clinical effectiveness and UAP relevance are not established.

Supplied main text and supplement read; original main layout incomplete
PaperS7587

DRUG-NEM: Optimizing drug combinations using single-cell perturbation response to account for intratumoral heterogeneity

Benedict Anchang, Kara L. Davis, Harris G. Fienberg, Brian D. Williamson, Sean C. Bendall, Loukia G. Karacosta, Robert Tibshirani, Garry P. Nolan, Sylvia K. Plevritis. ebi.ac.uk. April 13, 2018.

DRUG-NEM ranks drug combinations using selected single-cell signaling responses. Its short-term surrogates and fixed-subpopulation assumptions limit interpretation. Repeated analyses are not new patients, and cell-line validation does not establish clinical benefit. The supplied main text is read; supporting information remains missing.

Supplied main text and mathematics read; apparatus partial
PaperS7500

Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models

Bahareh Ajami, Nikolay Samusik, Peter Wieghofer, Peggy P. Ho, Andrea Crotti, Zach Bjornson, Marco Prinz, Wendy J. Fantl, Garry P. Nolan, Lawrence Steinman. med.stanford.edu. March 5, 2018.

Ajami, Nolan and colleagues analyse brain myeloid populations in mouse disease models. Mouse treatment findings do not establish human therapy or UAP-related illness. Pooling, statistical assumptions and inconsistencies constrain interpretation.

Paper, methods, figures and checklist read
PaperS7593

Commonly Occurring Cell Subsets in High-Grade Serous Ovarian Tumors Identified by Single-Cell Mass Cytometry

Veronica D. Gonzalez, Nikolay Samusik, Tiffany J. Chen, Erica S. Savig, Nima Aghaeepour, David A. Quigley, Ying-Wen Huang, Valeria Giangarrà, Alexander D. Borowsky, Neil E. Hubbard, Shih-Yu Chen, Guojun Han, Alan Ashworth, Thomas J. Kipps, Jonathan S. Berek, Garry P. Nolan, Wendy J. Fantl. ebi.ac.uk. February 13, 2018.

Mass cytometry identifies tumor-cell subsets and outcome associations in a small ovarian-cancer cohort. Dominant and hybrid clusters did not individually correlate with relapse. Same-cohort marker selection and missing independent validation limit interpretation; cell-line response is not demonstrated patient benefit.

Supplied author manuscript read; figures and supplement missing

A curated public selection. Source review describes what was read; it does not establish that a claim is true. Our research approach