BioParity.UFO / UAP research

50 papers for “Research methods”

Results

PaperS7763

A Reply to: Large Exomoons unlikely around Kepler-1625 b and Kepler-1708 b

David Kipping, Alex Teachey, Daniel A. Yahalomi, Ben Cassese, Billy Quarles, Steve Bryson, Brad Hansen, Judit Szulágyi, Chris Burke, Kevin Hardegree-Ullman. arxiv.org. January 18, 2024.

Kipping and nine coauthors dispute reductions and inference in the Kepler1625/1708 exomoon controversy using shared archival products. They retain that both candidates may not be real and need further observations; noise, detrending, injection geometry, limb-darkening and conditional false-positive assumptions limit inference. No independent moon or UAP detection follows.

Received manuscript text and layouts reviewed; originals and data gaps retained
PaperS7570

MAPS: pathologist-level cell type annotation from tissue images through machine learning

Muhammad Shaban, Yunhao Bai, Huaying Qiu, Shulin Mao, Jason Yeung, Yao Yu Yeo, Vignesh Shanmugam, Han Chen, Bokai Zhu, Jason L Weirather, Garry P Nolan, Margaret A Shipp, Scott J Rodig, Sizun Jiang, Faisal Mahmood. ebi.ac.uk. January 2, 2024.

MAPS uses expert-labelled protein-expression data to classify cells. The authors report strong results within datasets, while acknowledging leakage risk from splitting one patient’s CODEX image by cells. Performance falls across cohorts and competing methods sometimes do better. Nolan is a coauthor and supervisor; disclosed commercial interests, reporting differences and missing original materials accompany the findings.

Complete supplied article and supplement text read; original and tiny-label gaps
PaperS7679

Integration of spatial and single-cell data across modalities with weakly linked features

Shuxiao Chen, Bokai Zhu, Sijia Huang, John W Hickey, Kevin Z Lin, Michael Snyder, William J Greenleaf, Garry P Nolan, Nancy R Zhang, Zongming Ma. ebi.ac.uk. September 7, 2023.

This Nolan-coauthored study introduces MaxFuse, a computational method for aligning cell measurements across weakly linked data types. Benchmarks report gains on selected datasets; inferred spatial gene activity is distinguished from measurements actually made in each cell. Reused cell batches and tuned comparisons limit broader conclusions. The article explicitly attributes FDA Medical Countermeasures Initiative contracts and NIH support to Nolan, without reporting a secret approach or classified UAP programme.

Complete supplied XML text; original figures and supplements unreviewed
PaperS7749

Close Encounters of the Interstellar Kind: Examining the Capture of Interstellar Objects in Near Earth Orbit

Diptajyoti Mukherjee, Amir Siraj, Hy Trac, Abraham Loeb. arxiv.org. August 7, 2023.

Mukherjee, Siraj, Trac and Loeb simulate capture and retention of interstellar objects near Earth, then estimate populations and survey detectability under assumed incoming velocities, abundance, sizes and lifetimes. The manuscript identifies no actual captured interstellar object.

Complete supplied fourteen-page manuscript; conditional capture model
PaperS7692

Organization of the human intestine at single-cell resolution

John W. Hickey, Winston R. Becker, Stephanie A. Nevins, Aaron Horning, Almudena Espin Perez, Chenchen Zhu, Bokai Zhu, Bei Wei, Roxanne Chiu, Derek C. Chen, Daniel L. Cotter, Edward D. Esplin, Annika K. Weimer, Chiara Caraccio, Vishal Venkataraaman, Christian M. Schürch, Sarah Black, Maria Brbić, Kaidi Cao, Shuxiao Chen, Weiruo Zhang, Emma Monte, Nancy R. Zhang, Zongming Ma, Jure Leskovec, Zhengyan Zhang, Shin Lin, Teri Longacre, Sylvia K. Plevritis, Yiing Lin, Garry P. Nolan, William J. Greenleaf, Michael Snyder. pmc.ncbi.nlm.nih.gov. July 19, 2023.

This healthy-adult intestine atlas describes regional tissue composition and spatial organization in nine donors. Millions of cells and regional sections remain nested within donors. Predicted signalling and regulatory associations are hypotheses; subset validation overlaps one donor and does not establish a clinical or causal mechanism. Nolan is a corresponding coauthor and supervisor. Published funding and commercial disclosures provide ordinary research context, without establishing a classified approach or UAP programme.

Complete specialist supplied XML text; native apparatus unreviewed
PaperS7683

Expanded vacuum-stable gels for multiplexed high-resolution spatial histopathology

Yunhao Bai, Bokai Zhu, John-Paul Oliveria, Bryan J. Cannon, Dorien Feyaerts, Marc Bosse, Kausalia Vijayaragavan, Noah F. Greenwald, Darci Phillips, Christian M. Schürch, Samuel M. Naik, Edward A. Ganio, Brice Gaudilliere, Scott J. Rodig, Michael B. Miller, Michael Angelo, Sean C. Bendall, Xavier Rovira-Clavé, Garry P. Nolan, Sizun Jiang. pmc.ncbi.nlm.nih.gov. July 7, 2023.

This proof-of-concept study introduces ExPRESSO for higher-resolution imaging of archived tissue on existing mass-spectrometry platforms. The reported lateral enlargement is about 3.7-fold, with axial compression, edge distortion and marker-specific signal limits. Alzheimer’s examples use six individuals, not hundreds of patients; vessel counts and image fields are nested observations. Nolan’s disclosed FDA funding and instrument-company interests are explicit. The study does not report UAP patients, a secret government approach or a clinical diagnostic trial.

Complete supplied XML text; original figures and supplements unreviewed
PaperS7698

Dasatinib overcomes glucocorticoid resistance in B-cell acute lymphoblastic leukemia

Jolanda Sarno, Pablo Domizi, Yuxuan Liu, Milton Merchant, Christina Bligaard Pedersen, Dorra Jedoui, Astraea Jager, Garry P. Nolan, Giuseppe Gaipa, Sean C. Bendall, Felice-Alessio Bava, Kara L. Davis. pmc.ncbi.nlm.nih.gov. May 22, 2023.

This leukemia paper reports laboratory, mouse and limited human-sample findings. The primary-sample combination result at 48 hours does not improve apoptosis beyond steroid alone; longer-culture observations use two selected specimens. Mouse survival findings require qualification for unequal toxicity censoring. It does not establish human combination-treatment efficacy. Nolan is credited with resources and clinical data alongside a coauthor, without a named funding award or government/UAP approach in this article.

Partial specialist supplied XML; method section and apparatus unreviewed
PaperS7480

Multi-Band Acoustic Monitoring of Aerial Signatures

Andrew Mead, Sarah Little, Paul Sail, Michelle Tu, Wesley Andrés Watters, Abigail White, Richard Cloete. arxiv.org. May 5, 2023.

The Galileo team describes acoustic monitoring across three frequency bands, using known aircraft examples and proposed future analysis methods. This is an instrumentation paper, with no confirmed anomalous-object detection; Loeb is not a named author.

Paper text and figures read
PaperS7476

Overview of the Galileo Project

Abraham (Avi) Loeb, Frank H. Laukien. galileo.hsites.harvard.edu. February 13, 2023.

Loeb and Laukien outline instrument-based investigations of aerial phenomena, interstellar objects and meteor fragments. The paper describes a research programme and proposed methods, rather than a confirmed anomalous discovery.

Paper text read
PaperS7693

A tissue atlas of ulcerative colitis revealing evidence of sex-dependent differences in disease-driving inflammatory cell types and resistance to TNF inhibitor therapy

Aaron T Mayer, Derek R Holman, Anav Sood, Utkarsh Tandon, Salil S Bhate, Sunil Bodapati, Graham L Barlow, Jeff Chang, Sarah Black, Erica C Crenshaw, Alexander N Koron, Sarah E Streett, Sanjiv S Gambhir, William J Sandborn, Brigid S Boland, Trevor Hastie, Robert Tibshirani, John T Chang, Garry P Nolan, Christian M Schürch, Stephan Rogalla. pmc.ncbi.nlm.nih.gov. January 20, 2023.

This observational ulcerative-colitis atlas describes tissue organization in29patients and five controls. Cells and regions remain nested within individuals. Cross-sectional treatment and sex associations do not establish a resistance mechanism, and19-patient response prediction was unstable and nonsignificant. Nolan is a coauthor with published funding and commercial interests, not a corresponding author. These ordinary scientific attributions supply no classified approach or UAP programme evidence.

Complete root supplied XML text; native apparatus unreviewed
PaperS7491

Physical Considerations for an Intercept Mission to a 1I/'Oumuamua-like Interstellar Object

Amir Siraj, Abraham Loeb, Amaya Moro-Martin, Mark Elowitz, Abigail White, Wesley A. Watters, Gary J. Melnick, Richard Cloete, Jonathan Grindlay, Frank Laukien. arxiv.org. November 3, 2022.

Siraj, Loeb and colleagues outline requirements for a proposed interstellar-object intercept. Detection and reachability forecasts depend on assumptions; material analogues and modelled spectra do not identify an artificial object.

Preprint text and figures read
PaperS7764

"Down to Earth" Limits on Unidentified Aerial Phenomena in Ukraine (Comment on arXiv:2208.11215)

Abraham Loeb. arxiv.org. October 5, 2022.

Loeb argues that assumed high atmospheric speeds should produce strong frictional luminosity, and that a shorter inferred range could permit ordinary explanations. His conditional critique supplies no raw-observation refit or identified object. The paper acknowledges Galileo Project support and a Breakthrough Prize Foundation grant; it does not document the unnamed official visit separately reported in his book.

Supplied paper complete; author-host rendition separately collated

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