Erin Craig, Timothy J Keyes, Jolanda Sarno, Jeremy P D’Silva, Pablo Domizi, Maxim Zaslavsky, Albert Tsai, David Glass, Garry P Nolan, Trevor Hastie, Robert Tibshirani, Kara L Davis. ebi.ac.uk. August 27, 2025.
This Nolan-coauthored computational study estimates disease-associated cells using patient disease labels and a healthy baseline, without requiring expert cell annotations. Reported leukemia examples support a research method, with stronger expert-label benchmarks, small patient cohorts and assumptions that limit interpretation. Millions of measured cells do not imply millions of independent patients. Disclosed NIH support does not establish a classified programme or UAP access.
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