Paper · S7700
Postmitotic G1 phase survivin drives mitogen-independent cell division of B lymphocytes
This mouse-cell and laboratory-cell study examines continued B-cell division after removal of overt stimulation. Perturbation findings support a survivin-associated role within these models, while sufficiency and physiological generalization remain unestablished. Nolan contributed research and analytic tools; work-level public NIH/NIA support does not establish a classified or UAP approach.
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- Unique mouse count, sex and assay overlap unestablished; selected cells/nodes are dependent measurements, not patients.
- Survival support differs from renewed stimulation; not all cells divide. Excess cell death confounds a pathway-inhibitor test.
- Drug selectivity, target rescue, sufficiency, external validation and in-vivo/clinical relevance remain limited or untested.
- Caption/prose units, significance legends and fraction labels conflict; no silent correction.
- NIH/NIA support is work-level with no named individual recipient or award ID.
- Seven graphics, detailed SI, data, code, cited originals and version history unreviewed.
Cite this record
Amit Singh, Matthew H Spitzer, Jaimy P Joy, Mary Kaileh, Xiang Qiu, Garry P Nolan, Ranjan Sen. Postmitotic G1 phase survivin drives mitogen-independent cell division of B lymphocytes. April 27, 2022. BioParity S7700. https://bioparity.io/sources/S7700Record data (JSON)