BioParity.UFO / UAP research

64 papers for “Garry Nolan”

Results

PaperS7574

Reversibility of Defective Hematopoiesis Caused by Telomere Shortening in Telomerase Knockout Mice

Aparna Raval, Gregory K. Behbehani, Le Xuan Truong Nguyen, Daniel Thomas, Brenda Kusler, Alina Garbuzov, John Ramunas, Colin Holbrook, Christopher Y. Park, Helen Blau, Garry P. Nolan, Steven E. Artandi, Beverly S. Mitchell. journals.plos.org. July 2, 2015.

Selected mouse experiments report recovery of blood and cell readouts after telomerase reactivation, while finding no measurable telomere-length increase. Proposed explanations and a leukemia model remain separate from observations. Native cell-label, genotype, caption and statistical-bound conflicts persist. Nolan contributed analysis and tools and disclosed an instrument-manufacturer financial interest.

Defined supplied article and static apparatus read; raw and Word-layout gaps
PaperS7558

Mass cytometry as a platform for the discovery of cellular biomarkers to guide effective rheumatic disease therapy

Nitya Nair, Henrik E. Mei, Shih-Yu Chen, Matthew Hale, Garry P. Nolan, Holden T. Maecker, Mark Genovese, C. Garrison Fathman, Chan C. Whiting. ebi.ac.uk. May 18, 2015.

This 2015 review discusses mass cytometry as a possible aid to rheumatic-disease research. Its preliminary illustration compares one patient with one healthy control; concurrent treatment and assay timing limit interpretation. The authors explicitly consider residual drug neutralizing added TNF as an alternative to changed cell signaling. The illustration does not establish a validated biomarker or clinical recommendation. Nolan is a verified coauthor, while detailed individual contribution roles are not supplied.

Complete supplied review text and figures read
PaperS7579

Early reprogramming regulators identified by prospective isolation and mass cytometry

Ernesto Lujan, Eli R. Zunder, Yi Han Ng, Isabel N. Goronzy, Garry P. Nolan, Marius Wernig. ebi.ac.uk. April 1, 2015.

A mouse-cell study associates early reprogramming with a transient marker state, while showing that marker usefulness changes with time and model. Bulk colonies and unique reprogramming events are different outcomes. Limited replication, negative controls and speculative human extension remain explicit. The supplied manuscript text is read; full diagrams, tables and publisher corrections remain incomplete.

Complete supplied manuscript text read; meaningful apparatus partial
PaperS7563

Joint Modeling and Registration of Cell Populations in Cohorts of High-Dimensional Flow Cytometric Data

Saumyadipta Pyne, Sharon X. Lee, Kui Wang, Jonathan Irish, Pablo Tamayo, Marc-Danie Nazaire, Tarn Duong, Shu-Kay Ng, David Hafler, Ronald Levy, Garry P. Nolan, Jill Mesirov, Geoffrey J. McLachlan. ebi.ac.uk. July 1, 2014.

JCM models and registers cell populations across preprocessed flow-cytometry samples. Its demonstrations reuse three prior datasets, with manual gates, selected panels and selected benchmark samples. The implemented model restricts the general formulation. Exploratory results and nested cells do not establish prospective clinical prediction or independent replication. Nolan contributed materials, tools and writing. Source inconsistencies in timing, marker counts, tables, references and equations remain unresolved.

Complete supplied main and static supplements read

A curated public selection. Source review describes what was read; it does not establish that a claim is true. Our research approach