{"apiVersion":"1","version":"sha256:faade27e0b75b2aca6311142ff65347b4dacc153e8d28cbdf0e8a237319331f9","data":{"id":"S7703","title":"A Comprehensive Atlas of Immunological Differences Between Humans, Mice, and Non-Human Primates","authors":["Zachary B Bjornson-Hooper","Gabriela K Fragiadakis","Matthew H Spitzer","Han Chen","Deepthi Madhireddy","Kevin Hu","Kelly Lundsten","David R McIlwain","Garry P Nolan"],"publishedDate":"2022-03-11","format":"Paper","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8962947/","summary":"This comparative immune atlas describes differences among sampled humans, mice and non-human primates. Mouse blood was pooled into six tubes, and the human dataset overlaps a companion study. Selected differences face antibody-affinity and unexplained denominator limits. Nolan advised the study and edited the manuscript. FDA/NIH support is acknowledged without identifying all individual award recipients; it does not establish a UAP programme or private approach. Review excludes operational biological sections, Discussion and Methods.","subjects":["Research methods","Imaging"],"people":["Garry Nolan"],"review":{"label":"Partial specialist XML; operational sections and Methods excluded","scope":"Specialist read 43,308 permitted XML characters/493 nodes in ten untruncated returns, three captions and 75 references. Ten ranges totaling 45,121 characters remain excluded/unread. Root reviewed the entire analytical report/evidence only; no primary text or pixels reread.","gaps":["Fifty mice pooled into six sex-separated tubes; human data overlap a companion paper. Cells and mice are not independent pooled measurements.","Introductory rhesus count32 versus subset25 is unresolved; screen donors, animal selection/losses and pooling statistics remain unverified.","Antibody affinity/cross-reactivity limit marker interpretation; selected nulls, internal identity/AGM wording conflicts and batch data-not-shown preserved.","Ten operational/validation/result ranges, all Discussion/Methods and supplementary-caption groups remain unread; partial supplied scope, not whole article completion.","Seven graphics/native pages, supplementary bodies, repositories, code, reviewer reports and cited originals unreviewed. No patient records or clinical advice.","Nolan advised/edited. Work-level FDA/NIH recipients UNKNOWN; named personal support and shared award family preserved privately. Disclosures are not an audit or insider contact."]},"familyId":"NOLAN-COMPARATIVE-IMMUNE-ATLAS-2022-867015","citationUrl":"https://bioparity.io/sources/S7703","citation":"Zachary B Bjornson-Hooper, Gabriela K Fragiadakis, Matthew H Spitzer, Han Chen, Deepthi Madhireddy, Kevin Hu, Kelly Lundsten, David R McIlwain, Garry P Nolan. A Comprehensive Atlas of Immunological Differences Between Humans, Mice, and Non-Human Primates. March 11, 2022. BioParity S7703. https://bioparity.io/sources/S7703"}}