{"apiVersion":"1","version":"sha256:faade27e0b75b2aca6311142ff65347b4dacc153e8d28cbdf0e8a237319331f9","data":{"id":"S7701","title":"A multi-omics spatial framework for host-microbiome dissection within the intestinal tissue microenvironment","authors":["Bokai Zhu","Yunhao Bai","Yao Yu Yeo","Xiaowei Lu","Xavier Rovira-Clavé","Han Chen","Jason Yeung","Dingani Nkosi","Jonathan Glickman","Antonio Delgado-Gonzalez","Georg K. Gerber","Mike Angelo","Alex K. Shalek","Garry P. Nolan","Sizun Jiang"],"publishedDate":"2025-01-31","format":"Paper","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11785740/","summary":"This mouse-intestine study combines spatial imaging, gene-expression and glycan measurements to examine inflammation-associated patterns. Its many cells and regions come from eight main-cohort mice, and correlations do not establish microbial causation or clinical performance. Nolan is a corresponding author and joint supervisor. The reviewed scope is partial, with biological-validation sections and Methods excluded; public support and commercial disclosures do not establish a UAP programme or private approach.","subjects":["Imaging","Research methods"],"people":["Garry Nolan"],"review":{"label":"Partial specialist XML; validation and Methods excluded","scope":"Specialist read 77,367 permitted supplied XML characters in 11 untruncated returns, six captions and 69 references. Sec4, Sec10 and all Methods, totaling 48,677 characters, remain excluded/unread. Root reviewed the entire analytical packet; no primary-text or pixel reread.","gaps":["Main cohort: eight female six-week mice; 202 fields, 126,426 cells, 350 regions and 51 sections are nested measurements. Additional animal counts remain unreviewed.","Adjacent-section alignment, signal bleed-through and small bacterial panel limit inference. Human-tissue validation was beyond scope.","Selected correlations and condition-specific nulls remain; proximity and coexpression do not prove recruitment, signalling or microbial causation.","Classifier values, animal-grouped splits, stacking/leakage controls and independent validation are unverified within this partial scope, not proven absent.","Nolan is author 14 of 15, corresponding author/joint supervisor. His endowed professorship is distinct from other authors’ public grants; patent/commercial disclosures are not a financial audit or secret approach.","Sec4/Sec10/all Methods, seven graphics, supplements, source data, code, reviews and cited originals unreviewed. No individual patient records or clinical advice."]},"familyId":"NOLAN-MICROCART-2025-56237-7","citationUrl":"https://bioparity.io/sources/S7701","citation":"Bokai Zhu, Yunhao Bai, Yao Yu Yeo, Xiaowei Lu, Xavier Rovira-Clavé, Han Chen, Jason Yeung, Dingani Nkosi, Jonathan Glickman, Antonio Delgado-Gonzalez, Georg K. Gerber, Mike Angelo, Alex K. Shalek, Garry P. Nolan, Sizun Jiang. A multi-omics spatial framework for host-microbiome dissection within the intestinal tissue microenvironment. January 31, 2025. BioParity S7701. https://bioparity.io/sources/S7701"}}