{"apiVersion":"1","version":"sha256:faade27e0b75b2aca6311142ff65347b4dacc153e8d28cbdf0e8a237319331f9","data":{"id":"S7627","title":"Performance of BioFire array or QuickVue influenza A + B test versus a validation qPCR assay for detection of influenza A during a volunteer A/California/2009/H1N1 challenge study","authors":["David R McIlwain","Han Chen","Maria Apkarian","Melton Affrime","Bonnie Bock","Kenneth Kim","Nilanjan Mukherjee","Garry P Nolan","Monica M McNeal"],"publishedDate":"2021-02-25","format":"Paper","url":"https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7905982/fullTextXML","summary":"The authors compare BioFire and QuickVue tests with a study-specific qPCR comparator in selected influenza-challenge samples. Repeated matched swabs come from143 volunteers, and the two comparisons use different specimen sets. A linked correction changes the rapid-test table denominator from351 to299. These results do not establish performance in community infections, current product versions or UAP research.","subjects":["Garry Nolan research","Assay comparison","Source corrections"],"people":["Garry Nolan"],"review":{"label":"Complete supplied main, correction, native tables and offered static figures","scope":"Read32,968 main XML characters in five complete returns,24 references and44 physical cells with five blanks. Read the3,024-character correction and21 corrected-table cells with five blanks. Viewed two Venn figures and one supplemental gel page. Preserved Nolan’s joint design role, native no-competing-interest declaration, BARDA/NIH funding and Vaxart sample provision. The received main still carries the old table label despite the notice’s corrected-article statement.","gaps":["Both supplementary workbooks, original main/correction layouts, clipped raster-border glyphs, raw assay/clinical records, repositories and code remain unread or unreceived. A gel band alone does not establish sequence identity or uncropped provenance. No raw patient records, source formulas or scientific code were collected or executed.","351 BioFire and299 rapid-test comparisons are repeated matched-swab pairs rather than independent participants. Separate sets, prevalence, timing and comparator assumptions limit interpretation. qPCR accuracy was assumed; it is not independently established for every sample. The printed sensitivity confidence interval ends at79.5% in the abstract and79.4% elsewhere. Community generalization and predictive values are not inferred.","The correction repairs a typesetting denominator while retaining the individual counts; it does not reproduce or validate the whole study. Nolan is not the stated primary operator, analyst or manuscript writer. Funding/affiliation does not establish secret-programme access or UAP evidence. No present-day clinical advice or product recommendation follows."]},"familyId":"DOI-10.1186-S12985-021-01516-0","citationUrl":"https://bioparity.io/sources/S7627","citation":"David R McIlwain, Han Chen, Maria Apkarian, Melton Affrime, Bonnie Bock, Kenneth Kim, Nilanjan Mukherjee, Garry P Nolan, Monica M McNeal. Performance of BioFire array or QuickVue influenza A + B test versus a validation qPCR assay for detection of influenza A during a volunteer A/California/2009/H1N1 challenge study. February 25, 2021. BioParity S7627. https://bioparity.io/sources/S7627"}}