{"apiVersion":"1","version":"sha256:faade27e0b75b2aca6311142ff65347b4dacc153e8d28cbdf0e8a237319331f9","data":{"id":"S7610","title":"Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity","authors":["Lu Cui","Shih-Yu Chen","Tristan Lerbs","Jin-Wook Lee","Pablo Domizi","Sydney Gordon","Yong-hun Kim","Garry Nolan","Paola Betancur","Gerlinde Wernig"],"publishedDate":"2020-06-03","format":"Paper","url":"https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7270081/fullTextXML","summary":"The authors report JUN-associated changes in lung fibroblasts and test mechanisms and interventions in engineered cultures and mouse models. Eleven end-stage cases and three cancer-resection controls define the human comparison. Preclinical findings, sampling biases and explicit toxicity cautions prevent claims of proven treatment benefit or safety in patients.","subjects":["Garry Nolan research","Fibrosis mechanisms","Preclinical study limitations"],"people":["Garry Nolan"],"review":{"label":"Complete supplied main text; bounded supplemental visuals","scope":"Read74,690 version1 XML characters in ten complete returns,58 references, seven main images and eight native table cells. Read two supplemental PDFs’ extracted text in four returns,13 of18 information-page layouts, four published supplementary tables and all four reporting-form pages, including meaningful unextracted text on its last page. Nolan’s native byline is Garry Nolan and role is resources.","gaps":["Five supplemental visual pages,78 peer-review pages, a DOCX and three workbooks remain unread. Original main PDF, raw data and code remain unreviewed. An additive glyph qualification preserves the form’s instrument as Aria[I/l]iuSORP; exact model and correspondence to main instruments remain unknown.","Selected end-stage cases and cancer-resection controls are not a healthy volunteer cohort. Cells, fields, repeated cultures and mice are distinct units. Day4 semi-therapeutic mouse intervention and immune-deficient kidney-capsule grafts do not demonstrate benefit in patients.","Severe pulmonary side-effect and JUN systemic-toxicity cautions are explicit. Counts, diagnoses, sequencing platforms, assay labels, directions, statistics and reporting fields conflict within the supplied source. Funding and manuscript-review/IP context remain alongside the no-competing-interests declaration."]},"familyId":"DOI-10.1038-S41467-020-16466-4","citationUrl":"https://bioparity.io/sources/S7610","citation":"Lu Cui, Shih-Yu Chen, Tristan Lerbs, Jin-Wook Lee, Pablo Domizi, Sydney Gordon, Yong-hun Kim, Garry Nolan, Paola Betancur, Gerlinde Wernig. Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity. June 3, 2020. BioParity S7610. https://bioparity.io/sources/S7610"}}