{"apiVersion":"1","version":"sha256:faade27e0b75b2aca6311142ff65347b4dacc153e8d28cbdf0e8a237319331f9","data":{"id":"S7598","title":"TRAIL-induced variation of cell signaling states provides nonheritable resistance to apoptosis","authors":["Reema Baskar","Harris G Fienberg","Zumana Khair","Patricia Favaro","Sam Kimmey","Douglas R Green","Garry P Nolan","Sylvia Plevritis","Sean C Bendall"],"publishedDate":"2019-11-08","format":"Paper","url":"https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6848270/fullTextXML","summary":"This cultured-cell study examines variation in resistance to TRAIL-induced apoptosis. Responses differ across cell lines, and no universal resistant signaling state emerged. Reviewers questioned replication, causality and selected-marker diversity; the revised paper and small surviving fractions retain those limits.","subjects":["Garry Nolan research","Cell signaling","Peer-review limitations"],"people":["Garry Nolan"],"review":{"label":"Complete supplied main text and qualified apparatus reviewed","scope":"Read all82,907 supplied XML characters in11 complete returns,85 references and13 captions;13 small JPEGs,232 antibody-table cells and all23 review-history text pages. Four embedded review figures and only cover/end whole-page layouts were inspected. Root verified exact native text unions, nine authors and table values.","gaps":["Original main-paper PDF, Word layout,21 remaining review-page layouts, tiny figure lettering, raw FCS data and code remain unreviewed. The compiled review history is not the original correspondence formatting.","Cell counts are not independent biological replicates; some time courses used one replicate. Same-cell tracking was absent, and pre-existing resistant cells were not excluded. No patient efficacy, durable eradication, independent validation or UAP conclusion was established.","Native discrepancies in correlation direction, Pearson versus Spearman labels, cell-line captions, review-versus-final p-values and marker counts remain unresolved. Figures retain nonzero surviving fractions despite broader resistance-abrogation wording."]},"familyId":"DOI-10.26508-LSA.201900554","citationUrl":"https://bioparity.io/sources/S7598","citation":"Reema Baskar, Harris G Fienberg, Zumana Khair, Patricia Favaro, Sam Kimmey, Douglas R Green, Garry P Nolan, Sylvia Plevritis, Sean C Bendall. TRAIL-induced variation of cell signaling states provides nonheritable resistance to apoptosis. November 8, 2019. BioParity S7598. https://bioparity.io/sources/S7598"}}