{"apiVersion":"1","version":"sha256:faade27e0b75b2aca6311142ff65347b4dacc153e8d28cbdf0e8a237319331f9","data":{"id":"S7577","title":"An immune clock of human pregnancy","authors":["Nima Aghaeepour","Edward A. Ganio","David Mcilwain","Amy S. Tsai","Martha Tingle","Sofie Van Gassen","Dyani K. Gaudilliere","Quentin Baca","Leslie McNeil","Robin Okada","Mohammad S. Ghaemi","David Furman","Ronald J. Wong","Virginia D. Winn","Maurice L. Druzin","Yaser Y. El-Sayed","Cecele Quaintance","Ronald Gibbs","Gary L. Darmstadt","Gary M. Shaw","David K. Stevenson","Robert Tibshirani","Garry P. Nolan","David B. Lewis","Martin S. Angst","Brice Gaudilliere"],"publishedDate":"2017-09-01","format":"Paper","url":"https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5701281/fullTextXML","summary":"An observational immune model tracks term-pregnancy chronology in18 training and10 validation participants. Performance falls in validation; preterm pregnancies were excluded. Correlations do not establish causal immune mechanisms or preterm prediction. Source value, demographic and metadata conflicts accompany missing original article layouts and raw data. Nolan assisted interpretation and writing and disclosed equity interests.","subjects":["Pregnancy research","Immune modeling","Research limitations"],"people":["Garry Nolan"],"review":{"label":"Complete supplied main text and11-page supplement read; original main PDF and raw gaps","scope":"All61,343 main XML characters were read in eight complete returns, including49 references and56 physical table cells. Five native figures and two equation graphics were inspected. The complete11-page supplement totals16,196 text characters across four complete returns, with all pages, three figures and four tables viewed. Supporting tables contain1,452 physical cells, including960 checked/blank matrix values. Root matched the main character union and26 native authors. The XML mislabels the journal; the supplied supplement masthead identifies Science Immunology. Main publisher PDF was not received; exact font/layout fidelity and raw/code access remain gaps.","gaps":["Training includes18 term pregnancies after excluding three preterm births; validation includes ten term pregnancies. Repeated timepoints and bootstrap runs are dependent samples, not new participants. This does not validate preterm prediction or clinical use.","Reported correlation falls from0.89 in cross-validation to0.62 in validation. Whole-patient time series were held out together, but two women’s stimulation features were mean-imputed; imputation inside each fold is unverified. One proteomics participant failed quality control.","Some apparent stimulation changes disappear after controlling basal activity. IL2 direction of causality is unresolved. Prose/caption P-value exponents, demographic count/percentage pairs, cell signs and missing antibody concentrations remain unreconciled.","Original main PDF, raw patient-level records, source code and reanalysis were not acquired. Nolan’s role is interpretation/writing, with Fluidigm and BD equity disclosed. No UAP cohort, government approach or independent clinical replication appears."]},"familyId":"DOI-10.1126-SCIIMMUNOL.AAN2946","citationUrl":"https://bioparity.io/sources/S7577","citation":"Nima Aghaeepour, Edward A. Ganio, David Mcilwain, Amy S. Tsai, Martha Tingle, Sofie Van Gassen, Dyani K. Gaudilliere, Quentin Baca, Leslie McNeil, Robin Okada, Mohammad S. Ghaemi, David Furman, Ronald J. Wong, Virginia D. Winn, Maurice L. Druzin, Yaser Y. El-Sayed, Cecele Quaintance, Ronald Gibbs, Gary L. Darmstadt, Gary M. Shaw, David K. Stevenson, Robert Tibshirani, Garry P. Nolan, David B. Lewis, Martin S. Angst, Brice Gaudilliere. An immune clock of human pregnancy. September 1, 2017. BioParity S7577. https://bioparity.io/sources/S7577"}}