{"apiVersion":"1","version":"sha256:faade27e0b75b2aca6311142ff65347b4dacc153e8d28cbdf0e8a237319331f9","data":{"id":"S7574","title":"Reversibility of Defective Hematopoiesis Caused by Telomere Shortening in Telomerase Knockout Mice","authors":["Aparna Raval","Gregory K. Behbehani","Le Xuan Truong Nguyen","Daniel Thomas","Brenda Kusler","Alina Garbuzov","John Ramunas","Colin Holbrook","Christopher Y. Park","Helen Blau","Garry P. Nolan","Steven E. Artandi","Beverly S. Mitchell"],"publishedDate":"2015-07-02","format":"Paper","url":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131722","summary":"Selected mouse experiments report recovery of blood and cell readouts after telomerase reactivation, while finding no measurable telomere-length increase. Proposed explanations and a leukemia model remain separate from observations. Native cell-label, genotype, caption and statistical-bound conflicts persist. Nolan contributed analysis and tools and disclosed an instrument-manufacturer financial interest.","subjects":["Telomerase","Mouse experiments","Research limitations"],"people":["Garry Nolan"],"review":{"label":"Defined supplied article and static apparatus read; raw and Word-layout gaps","scope":"All61,394 decoded article characters were read in eight complete returns, including60 references. The original20-page publisher PDF, seven main figures and table were read in text and pixels. All13 supplied DOCX texts total10,878 characters; ten supplementary figures and eleven unique embedded plots were inspected. Exact duplicate EMF pairs were excluded. An additive correction fixes receipt metadata counts to6×2 and35×5 supporting tables,187 physical cells; root compared every row against original Word XML while preserving erroneous frozen metadata. Original Word-page collation, raw and unshown results and code remain unreviewed.","gaps":["Small mouse samples, repeated pre/post animals, pooled experiments and nested cells are dependent observations. They do not establish human therapeutic efficacy, safety or independent replication.","No measurable telomere-length increase was reported. Shortest-telomere extension is an explanation; the proposed leukemia arrow is not an observed longitudinal cancer outcome. Several negative results have no supplied underlying data.","GMP/MEP, Sca1/CD150 signs, control genotype and species-caption conflicts remain unresolved. Figure7 labels human cells above mouse panels; S10 names GMP but supplied plots show MEP. Statistical upper bounds do not supply exact probabilities or prove conventional significance.","Raw FCS, original microscopy, uncropped gels, unshown results, code and original Word layouts remain missing. Nolan’s role is data analysis and tools, with DVS Sciences personal financial interest. No UAP cohort or government programme appears."]},"familyId":"DOI-10.1371-JOURNAL.PONE.0131722","citationUrl":"https://bioparity.io/sources/S7574","citation":"Aparna Raval, Gregory K. Behbehani, Le Xuan Truong Nguyen, Daniel Thomas, Brenda Kusler, Alina Garbuzov, John Ramunas, Colin Holbrook, Christopher Y. Park, Helen Blau, Garry P. Nolan, Steven E. Artandi, Beverly S. Mitchell. Reversibility of Defective Hematopoiesis Caused by Telomere Shortening in Telomerase Knockout Mice. July 2, 2015. BioParity S7574. https://bioparity.io/sources/S7574"}}