Results

PaperS7555

CellSeg: a robust, pre-trained nucleus segmentation and pixel quantification software for highly multiplexed fluorescence images

Michael Y. Lee, Jacob S. Bedia, Salil S. Bhate, Graham L. Barlow, Darci Phillips, Wendy J. Fantl, Garry P. Nolan, Christian M. Schürch. ebi.ac.uk. January 18, 2022.

CellSeg combines a pretrained nucleus-segmentation model with image scaling, stitching, mask expansion and pixel statistics. Historical benchmark scores and representative tissue examples have different provenance and settings; densely packed tissue remains difficult. A colorectal comparison reuses 140 samples from 35 people and provides author-described gating and correlation. Correlation does not establish exhaustive cell truth or universal clinical accuracy. Source-native metric definitions, count conflicts and caption errors are preserved.

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PaperS7562

MIBI-TOF: A multiplexed imaging platform relates cellular phenotypes and tissue structure

Leeat Keren, Marc Bosse, Steve Thompson, Tyler Risom, Kausalia Vijayaragavan, Erin McCaffrey, Diana Marquez, Roshan Angoshtari, Noah F. Greenwald, Harris Fienberg, Jennifer Wang, Neeraja Kambham, David Kirkwood, Garry Nolan, Thomas J. Montine, Stephen J. Galli, Robert West, Sean C. Bendall, Michael Angelo. ebi.ac.uk. October 9, 2019.

The authors describe a multiplexed tissue-imaging instrument and its performance under specific settings. The main tumor demonstration uses one patient, eight regions and 11,120 nested cells; a 41-patient comparison reuses earlier work. Static spatial patterns do not establish causal immune recruitment or clinical prediction. Nolan supported the work and held patent and shareholder interests. Sensitivity, depth counts, figure settings and panel recipes contain unresolved inconsistencies.

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PaperS103

The New Science of Unidentified Aerospace-Undersea Phenomena

Kevin H. Knuth, Philippe Ailleris, Hussein Ali Agrama, Eamonn Ansbro, Phyllis A. Budinger, Tejin Cai, Thibaut Canuti, Michael C. Cifone, Walter Bruce Cornet, Jr., Frédéric Courtade, Richard Dolan, Laura Domine, Luc Dini, Baptiste Friscourt, Ryan Graves, Richard F. Haines, Richard Hoffman, Hakan Kayal, Sarah Little, Garry P. Nolan, Robert Powell, Mark Rodeghier, Edoardo Russo, Peter Skafish, Erling Strand, Michael Swords, Matthew Szydagis, Gerald T. Tedesco, John J. Tedesco, Massimo Teodorani, Jacques Vallée, Michaël Vaillant, Beatriz Villarroel, Wesley A. Watters. arxiv.org. 2025.

This coauthored review surveys reported aerospace and undersea phenomena, historical cases and proposed research. Selected figure pages distinguish drawings, photographs, material reports and hypothetical interpretations. Its coauthors and reproduced cases do not supply independent verification of underlying events, anomalous materials or government programmes.

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A curated public selection. Source review describes what was read; it does not establish that a claim is true. Our research approach